HIV protease cleaves the antiviral m(6)A reader protein YTHDF3 in the viral particle

N(6)-methyladenosine (m(6)A) is the most abundant HIV RNA modification but the interplay between the m(6)A reader protein YTHDF3 and HIV replication is not well understood. We found that knockout of YTHDF3 in human CD4+ T-cells increases infection supporting the role of YTHDF3 as a restriction facto...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Jurczyszak, Denise, Zhang, Wen, Terry, Sandra N., Kehrer, Thomas, Bermúdez González, Maria C., McGregor, Emma, Mulder, Lubbertus C. F., Eckwahl, Matthew J., Pan, Tao, Simon, Viviana
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043784/
https://ncbi.nlm.nih.gov/pubmed/32053707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008305
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