HIV protease cleaves the antiviral m(6)A reader protein YTHDF3 in the viral particle

N(6)-methyladenosine (m(6)A) is the most abundant HIV RNA modification but the interplay between the m(6)A reader protein YTHDF3 and HIV replication is not well understood. We found that knockout of YTHDF3 in human CD4+ T-cells increases infection supporting the role of YTHDF3 as a restriction facto...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Jurczyszak, Denise, Zhang, Wen, Terry, Sandra N., Kehrer, Thomas, Bermúdez González, Maria C., McGregor, Emma, Mulder, Lubbertus C. F., Eckwahl, Matthew J., Pan, Tao, Simon, Viviana
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043784/
https://ncbi.nlm.nih.gov/pubmed/32053707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008305
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