A54 DELTA OPIOID RECEPTOR SIGNALING MEDIATES OPIOID INDUCED TOLERANCE AND HYPERALGESIA IN COLONIC SENSORY NERVES

BACKGROUND: While opioid drugs are widely used for treating abdominal pain, prolonged exposure to opioids can induce tolerance and paradoxically increase pain. We previously showed in colonic afferent nerves that chronic morphine treatment causes tolerance and paradoxical hyperalgesia, however the m...

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Bibliografske podrobnosti
izdano v:J Can Assoc Gastroenterol
Main Authors: Jaramillo Polanco, J O, Lopez Lopez, C D, Yu, Y, Reed, D E, Lomax, A E, Vanner, S
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Poster of Distinction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043528/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz047.053
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