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A53 CHRONIC MORPHINE TREATMENT CAUSES TOLERANCE AND INCREASES PAIN SIGNALING FOLLOWING ACUTE MORPHINE APPLICATION TO MOUSE VISCERAL SENSORY NERVES
BACKGROUND: Opioid drugs are efficacious for treating abdominal pain but prolonged exposure to opioids in patients induces tolerance, which in turn can lead to escalating doses to achieve an analgesic effect. Furthermore, these increasing doses can activate pronociceptive signaling but the mechanism...
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| Publicado no: | J Can Assoc Gastroenterol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6512727/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz006.052 |
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