A90 A UTILITY-BASED BAYESIAN OPTIMAL INTERVAL (U-BOIN) PHASE I/II DESIGN TO IDENTIFY THE OPTIMAL BIOLOGICAL DOSE FOR TARGETED AND IMMUNE THERAPIES

BACKGROUND: In the era of targeted therapy and immunotherapy, the objective of dose finding is often to identify the optimal biological dose (OBD), rather than the maximum tolerated dose (MTD). AIMS: To develop a utility-based Bayesian optimal interval (U-BOIN) phase I/II design to find the OBD. MET...

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Vydáno v:J Can Assoc Gastroenterol
Hlavní autoři: Zhou, Y, Lee, J, Yuan, Y
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Poster Presentation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043509/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz047.089
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