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A90 A UTILITY-BASED BAYESIAN OPTIMAL INTERVAL (U-BOIN) PHASE I/II DESIGN TO IDENTIFY THE OPTIMAL BIOLOGICAL DOSE FOR TARGETED AND IMMUNE THERAPIES
BACKGROUND: In the era of targeted therapy and immunotherapy, the objective of dose finding is often to identify the optimal biological dose (OBD), rather than the maximum tolerated dose (MTD). AIMS: To develop a utility-based Bayesian optimal interval (U-BOIN) phase I/II design to find the OBD. MET...
שמור ב:
| הוצא לאור ב: | J Can Assoc Gastroenterol |
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| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7043509/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz047.089 |
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