Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A Nonrandomized Phase 1/2 Clinical Trial

IMPORTANCE: Active therapeutic combinations, such as trabectedin and radiotherapy, offer potentially higher dimensional response in second-line treatment of advanced soft-tissue sarcomas. Dimensional response can be relevant both for symptom relief and for survival. OBJECTIVE: To assess the combined...

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Опубликовано в: :JAMA Oncol
Главные авторы: Martin-Broto, Javier, Hindi, Nadia, Lopez-Pousa, Antonio, Peinado-Serrano, Javier, Alvarez, Rosa, Alvarez-Gonzalez, Ana, Italiano, Antoine, Sargos, Paul, Cruz-Jurado, Josefina, Isern-Verdum, Josep, Dolado, Maria Carmen, Rincon-Pérez, Inmaculada, Sanchez-Bustos, Paloma, Gutierrez, Antonio, Romagosa, Cleofe, Morosi, Carlo, Grignani, Giovanni, Gatti, Marco, Luna, Pablo, Alastuey, Ignacio, Redondo, Andres, Belinchon, Belen, Martinez-Serra, Jordi, Sunyach, Marie-Pierre, Coindre, Jean-Michel, Dei Tos, Angelo P., Romero, Jesus, Gronchi, Alessandro, Blay, Jean-Yves, Moura, David S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Medical Association 2020
Предметы:
Original Investigation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042948/
https://ncbi.nlm.nih.gov/pubmed/32077895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.6584
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