Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems. [Image: see text]

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Bibliografische gegevens
Gepubliceerd in:Cancer Med
Hoofdauteurs: Italiano, Antoine, Touati, Nathan, Litière, Saskia, Collin, Françoise, Pourquier, Philippe, Gronchi, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
Onderwerpen:
Clinical Cancer Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943428/
https://ncbi.nlm.nih.gov/pubmed/29656586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1403
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