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Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation
This study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfused rat liver (IPRL) studies have been reported not to be consistent with the well stirred model of organ elimination when only entering and exiting liver concentration measurements are available. First...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Drug Metab Dispos |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7042717/ https://ncbi.nlm.nih.gov/pubmed/31563869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088872 |
| Tagiau: |
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