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Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation

This study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfused rat liver (IPRL) studies have been reported not to be consistent with the well stirred model of organ elimination when only entering and exiting liver concentration measurements are available. First...

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Bibliografische gegevens
Gepubliceerd in:Drug Metab Dispos
Hoofdauteurs: Wang, Hong-Jaan, Benet, Leslie Z.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042717/
https://ncbi.nlm.nih.gov/pubmed/31563869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088872
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