The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver

BACKGROUND AND PURPOSE: The normal liver sinusoidal endothelium is thin and punctuated with fenestrations 50–200 nm in diameter that filter endobiotics and xenobiotics. Defenestration of the liver sinusoidal endothelium in old age and after pre-treatment with poloxamer-407 (P407) has been shown to p...

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Detalhes bibliográficos
Publicado no:Pharmacology
Main Authors: Mitchell, Sarah J., Huizer-Pajkos, Aniko, Cogger, Victoria C., McLachlan, Andrew J., Le Couteur, David G., Jones, Brett, de Cabo, Rafael, Hilmer, Sarah N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976489/
https://ncbi.nlm.nih.gov/pubmed/23007459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000341724
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