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The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver
BACKGROUND AND PURPOSE: The normal liver sinusoidal endothelium is thin and punctuated with fenestrations 50–200 nm in diameter that filter endobiotics and xenobiotics. Defenestration of the liver sinusoidal endothelium in old age and after pre-treatment with poloxamer-407 (P407) has been shown to p...
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| Publicado en: | Pharmacology |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5976489/ https://ncbi.nlm.nih.gov/pubmed/23007459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000341724 |
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