The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin encodes the μ subunit of the AP-2 adaptin trafficking complex....

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Veröffentlicht in:mBio
Hauptverfasser: Henrici, Ryan C., Edwards, Rachel L., Zoltner, Martin, van Schalkwyk, Donelly A., Hart, Melissa N., Mohring, Franziska, Moon, Robert W., Nofal, Stephanie D., Patel, Avnish, Flueck, Christian, Baker, David A., Odom John, Audrey R., Field, Mark C., Sutherland, Colin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042695/
https://ncbi.nlm.nih.gov/pubmed/32098816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02918-19
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