The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin encodes the μ subunit of the AP-2 adaptin trafficking complex....

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Publicat a:mBio
Autors principals: Henrici, Ryan C., Edwards, Rachel L., Zoltner, Martin, van Schalkwyk, Donelly A., Hart, Melissa N., Mohring, Franziska, Moon, Robert W., Nofal, Stephanie D., Patel, Avnish, Flueck, Christian, Baker, David A., Odom John, Audrey R., Field, Mark C., Sutherland, Colin J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042695/
https://ncbi.nlm.nih.gov/pubmed/32098816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02918-19
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