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Structural basis for two-way communication between dynein and microtubules

The movements of cytoplasmic dynein on microtubule (MT) tracks is achieved by two-way communication between the microtubule-binding domain (MTBD) and the ATPase domain via a coiled-coil stalk, but the structural basis of this communication remains elusive. Here, we regulate MTBD either in high-affin...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nishida, Noritaka, Komori, Yuta, Takarada, Osamu, Watanabe, Atsushi, Tamura, Satoko, Kubo, Satoshi, Shimada, Ichio, Kikkawa, Masahide
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042235/
https://ncbi.nlm.nih.gov/pubmed/32098965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14842-8
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