Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

G protein-coupled receptors (GPCRs) signal through allostery, and it is increasingly clear that chemically distinct agonists can produce different receptor-based effects. It has been proposed that agonists selectively promote receptors to recruit one cellular interacting partner over another, introd...

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Опубликовано в: :eLife
Главные авторы: Stoeber, Miriam, Jullié, Damien, Li, Joy, Chakraborty, Soumen, Majumdar, Susruta, Lambert, Nevin A, Manglik, Aashish, von Zastrow, Mark
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Biochemistry and Chemical Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041944/
https://ncbi.nlm.nih.gov/pubmed/32096468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54208
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