Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells

This report addresses whether small molecules can deplete FoxP3-expressing regulatory T (T reg) cells, thereby augmenting antitumor immunity. Imatinib, a tyrosine kinase inhibitor of oncogenic BCR-ABL protein expressed by chronic myelogenous leukemia (CML) cells, possesses off-targets including LCK...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Tanaka, Atsushi, Nishikawa, Hiroyoshi, Noguchi, Shinsuke, Sugiyama, Daisuke, Morikawa, Hiromasa, Takeuchi, Yoshiko, Ha, Danbee, Shigeta, Naoya, Kitawaki, Toshio, Maeda, Yuka, Saito, Takuro, Shinohara, Yoshinori, Kameoka, Yoshihiro, Iwaisako, Keiko, Monma, Fumihiko, Ohishi, Kohshi, Karbach, Julia, Jäger, Elke, Sawada, Kenichi, Katayama, Naoyuki, Takahashi, Naoto, Sakaguchi, Shimon
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041710/
https://ncbi.nlm.nih.gov/pubmed/31704808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191009
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