PD-1(+) regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

PD-1 blockade is a cancer immunotherapy effective in various types of cancer. In a fraction of treated patients, however, it causes rapid cancer progression called hyperprogressive disease (HPD). With our observation of HPD in ∼10% of anti–PD-1 monoclonal antibody (mAb)-treated advanced gastric canc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kamada, Takahiro, Togashi, Yosuke, Tay, Christopher, Ha, Danbee, Sasaki, Akinori, Nakamura, Yoshiaki, Sato, Eiichi, Fukuoka, Shota, Tada, Yasuko, Tanaka, Atsushi, Morikawa, Hiromasa, Kawazoe, Akihito, Kinoshita, Takahiro, Shitara, Kohei, Sakaguchi, Shimon, Nishikawa, Hiroyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525547/
https://ncbi.nlm.nih.gov/pubmed/31028147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1822001116
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