A super enhancer controls expression and chromatin architecture within the MHC class II locus

Super enhancers (SEs) play critical roles in cell type–specific gene regulation. The mechanisms by which such elements work are largely unknown. Two SEs termed DR/DQ-SE and XL9-SE are situated within the human MHC class II locus between the HLA-DRB1 and HLA-DQA1 genes and are highly enriched for dis...

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Vydáno v:J Exp Med
Hlavní autoři: Majumder, Parimal, Lee, Joshua T., Rahmberg, Andrew R., Kumar, Gaurav, Mi, Tian, Scharer, Christopher D., Boss, Jeremy M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041702/
https://ncbi.nlm.nih.gov/pubmed/31753848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190668
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