RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking

High RanGTP around chromatin is important for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects of importin α/β. Here we examine how the Ran gradient regulates Kinesin-14 function to control spindle organization. We show that Xenopus Kinesin-14, XCTK2, and imp...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Ems-McClung, Stephanie C., Emch, Mackenzie, Zhang, Stephanie, Mahnoor, Serena, Weaver, Lesley N., Walczak, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041689/
https://ncbi.nlm.nih.gov/pubmed/31865374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201906045
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