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RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking
High RanGTP around chromatin is important for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects of importin α/β. Here we examine how the Ran gradient regulates Kinesin-14 function to control spindle organization. We show that Xenopus Kinesin-14, XCTK2, and imp...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7041689/ https://ncbi.nlm.nih.gov/pubmed/31865374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201906045 |
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