Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12

Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self‐assembly in the solid state. In particular, we report the crystal structures of two halogen‐modified sequences, which we fou...

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Detaylı Bibliyografya
Yayımlandı:ChemistryOpen
Asıl Yazarlar: Maiolo, Daniele, Pizzi, Andrea, Gori, Alessandro, Gazzera, Lara, Demitri, Nicola, Genoni, Alessandro, Baggi, Fulvio, Moda, Fabio, Terraneo, Giancarlo, Baldelli Bombelli, Francesca, Metrangolo, Pierangelo, Resnati, Giuseppe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Full Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041548/
https://ncbi.nlm.nih.gov/pubmed/32110506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900350
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