Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12

Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self‐assembly in the solid state. In particular, we report the crystal structures of two halogen‐modified sequences, which we fou...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ChemistryOpen
Päätekijät: Maiolo, Daniele, Pizzi, Andrea, Gori, Alessandro, Gazzera, Lara, Demitri, Nicola, Genoni, Alessandro, Baggi, Fulvio, Moda, Fabio, Terraneo, Giancarlo, Baldelli Bombelli, Francesca, Metrangolo, Pierangelo, Resnati, Giuseppe
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Full Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041548/
https://ncbi.nlm.nih.gov/pubmed/32110506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900350
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