Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12

Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self‐assembly in the solid state. In particular, we report the crystal structures of two halogen‐modified sequences, which we fou...

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Maiolo, Daniele, Pizzi, Andrea, Gori, Alessandro, Gazzera, Lara, Demitri, Nicola, Genoni, Alessandro, Baggi, Fulvio, Moda, Fabio, Terraneo, Giancarlo, Baldelli Bombelli, Francesca, Metrangolo, Pierangelo, Resnati, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041548/
https://ncbi.nlm.nih.gov/pubmed/32110506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900350
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