Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis

BACKGROUND: There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion molecules that augment thrombosis by activating immune cells to initiate the coagulation cascade. GMI‐1271, a potent small‐molecule E‐sel...

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Detalhes bibliográficos
Publicado no:Res Pract Thromb Haemost
Main Authors: Devata, Sumana, Angelini, Dana E., Blackburn, Susan, Hawley, Angela, Myers, Daniel D., Schaefer, Jordan K., Hemmer, Martina, Magnani, John L., Thackray, Helen M., Wakefield, Thomas W., Sood, Suman L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles: Thrombosis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040550/
https://ncbi.nlm.nih.gov/pubmed/32110749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12279
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