E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271

Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme critical to the generation of E-selectin ligands, in MM BM homing and resistance...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Natoni, A, Smith, T A G, Keane, N, McEllistrim, C, Connolly, C, Jha, A, Andrulis, M, Ellert, E, Raab, M S, Glavey, S V, Kirkham-McCarthy, L, Kumar, S K, Locatelli-Hoops, S C, Oliva, I, Fogler, W E, Magnani, J L, O'Dwyer, M E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729350/
https://ncbi.nlm.nih.gov/pubmed/28439107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.123
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