Functional Dissection of the Retrograde Shiga Toxin Trafficking Inhibitor Retro-2

The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes, and relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by which...

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Publicado en:Nat Chem Biol
Autores principales: Forrester, Alison, Rathjen, Stefan J., Garcia-Castillo, Maria Daniela, Bachert, Collin, Couhert, Audrey, Tepshi, Livia, Pichard, Sylvain, Martinez, Jennifer, Munier, Mathilde, Sierocki, Raphael, Renard, Henri-François, Valades-Cruz, César Augusto, Dingli, Florent, Loew, Damarys, Lamaze, Christophe, Cintrat, Jean-Christophe, Linstedt, Adam D., Gillet, Daniel, Barbier, Julien, Johannes, Ludger
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039708/
https://ncbi.nlm.nih.gov/pubmed/32080624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0474-4
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