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(S)-N-Methyldihydroquinazolinones are the Active Enantiomers of Retro-2 Derived Compounds against Toxins

[Image: see text] This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of a new compound, named Retro-2.1, active against toxins by inhibiting intracellular trafficking via the retrograde route. The absolute configuration of the bioactiv...

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Detalhes bibliográficos
Main Authors: Gupta, Neetu, Pons, Valérie, Noël, Romain, Buisson, David-Alexandre, Michau, Aurélien, Johannes, Ludger, Gillet, Daniel, Barbier, Julien, Cintrat, Jean-Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027625/
https://ncbi.nlm.nih.gov/pubmed/24900779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400457j
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