Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli

The most deadly outbreak of Escherichia coli O104:H4 occurred in Europe in 2011. Here, we evaluated the effects of the retrograde trafficking inhibitor Retro-2(cycl) in a murine model of E. coli O104:H4 infection. Systemic treatment with Retro-2(cycl) significantly reduced body weight loss and impro...

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Spremljeno u:
Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Secher, T., Shima, A., Hinsinger, K., Cintrat, J. C., Johannes, L., Barbier, J., Gillet, D., Oswald, E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Clinical Therapeutics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505253/
https://ncbi.nlm.nih.gov/pubmed/25987610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00455-15
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