Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we use single cell RNA-seq analysis to characterize latency in monocytes a...

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Udgivet i:eLife
Main Authors: Shnayder, Miri, Nachshon, Aharon, Rozman, Batsheva, Bernshtein, Biana, Lavi, Michael, Fein, Noam, Poole, Emma, Avdic, Selmir, Blyth, Emily, Gottlieb, David, Abendroth, Allison, Slobedman, Barry, Sinclair, John, Stern-Ginossar, Noam, Schwartz, Michal
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Microbiology and Infectious Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039680/
https://ncbi.nlm.nih.gov/pubmed/31967545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52168
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