Human Cytomegalovirus-Encoded Human Interleukin-10 (IL-10) Homolog Amplifies Its Immunomodulatory Potential by Upregulating Human IL-10 in Monocytes

The human cytomegalovirus (HCMV) gene UL111A encodes cytomegalovirus-encoded human interleukin-10 (cmvIL-10), a homolog of the potent immunomodulatory cytokine human interleukin 10 (hIL-10). This viral homolog exhibits a range of immunomodulatory functions, including suppression of proinflammatory c...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Avdic, Selmir, McSharry, Brian P., Steain, Megan, Poole, Emma, Sinclair, John, Abendroth, Allison, Slobedman, Barry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
Onderwerpen:
Pathogenesis and Immunity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810557/
https://ncbi.nlm.nih.gov/pubmed/26792743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03066-15
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