Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses

Several human cytomegalovirus (HCMV) genes encode products that modulate cellular functions in a manner likely to enhance viral pathogenesis. This includes UL111A, which encodes homologs of human interleukin-10 (hIL-10). Depending upon signals received, monocytes and macrophages become polarized to...

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Detalhes bibliográficos
Main Authors: Avdic, Selmir, Cao, John Z., McSharry, Brian P., Clancy, Leighton E., Brown, Rebecca, Steain, Megan, Gottlieb, David J., Abendroth, Allison, Slobedman, Barry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754025/
https://ncbi.nlm.nih.gov/pubmed/23864618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00912-13
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