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A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3(+) T(reg) cell development
The neonatal thymus generates Foxp3(+) regulatory T (tT(reg)) cells that are critical in controlling immune homeostasis and preventing multi-organ autoimmunity. The role of antigen specificity on neonatal tT(reg) cell selection is unresolved. Here we identify seventeen self-peptides recognized by ne...
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| Published in: | Nat Immunol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7039339/ https://ncbi.nlm.nih.gov/pubmed/31209405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0414-1 |
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