A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands

A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How individual αβTCRs are constructed to specifically recognize a limited set of MHC ligands is unclear. Here...

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Hlavní autoři: Stadinski, Brian D., Trenh, Peter, Smith, Rebecca L., Bautista, Bianca, Huseby, Priya G., Li, Guoqi, Stern, Lawrence J., Huseby, Eric S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253227/
https://ncbi.nlm.nih.gov/pubmed/22101158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.10.012
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