Conformational Plasticity of the Immunoglobulin Fc Domain in Solution

Fragment crystallizable (Fc) region of immunoglobulin G (IgG) antibody binds to specific Fc receptors (FcγRs) to control antibody effector functions. Currently, engineered specific Fc-FcγR interactions are validated with a static conformation derived from the crystal structure. However, computationa...

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Bibliografiska uppgifter
I publikationen:Structure
Huvudupphovsmän: Remesh, Soumya G., Armstrong, Anthony A., Mahan, Andrew D., Luo, Jinquan, Hammel, Michal
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039147/
https://ncbi.nlm.nih.gov/pubmed/29731233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.03.017
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