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Conformational Plasticity of the Immunoglobulin Fc Domain in Solution
Fragment crystallizable (Fc) region of immunoglobulin G (IgG) antibody binds to specific Fc receptors (FcγRs) to control antibody effector functions. Currently, engineered specific Fc-FcγR interactions are validated with a static conformation derived from the crystal structure. However, computationa...
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| Publicado no: | Structure |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7039147/ https://ncbi.nlm.nih.gov/pubmed/29731233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.03.017 |
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