APE1 senses DNA single-strand breaks for repair and signaling

DNA single-strand breaks (SSBs) represent the most abundant type of DNA damage. Unrepaired SSBs impair DNA replication and transcription, leading to cancer and neurodegenerative disorders. Although PARP1 and XRCC1 are implicated in the SSB repair pathway, it remains unclear how SSB repair and SSB si...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Lin, Yunfeng, Raj, Jude, Li, Jia, Ha, Anh, Hossain, Md Akram, Richardson, Christine, Mukherjee, Pinku, Yan, Shan
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038996/
https://ncbi.nlm.nih.gov/pubmed/31828326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1175
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