Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

Imbalance in the level of the pyrimidine degradation products dihydrouracil and dihydrothymine is associated with cellular transformation and cancer progression. Dihydropyrimidines are degraded by dihydropyrimidinase (DHP), a zinc metalloenzyme that is upregulated in solid tumors but not in the corr...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Basbous, Jihane, Aze, Antoine, Chaloin, Laurent, Lebdy, Rana, Hodroj, Dana, Ribeyre, Cyril, Larroque, Marion, Shepard, Caitlin, Kim, Baek, Pruvost, Alain, Moreaux, Jérôme, Maiorano, Domenico, Mechali, Marcel, Constantinou, Angelos
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038975/
https://ncbi.nlm.nih.gov/pubmed/31853544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1162
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