Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in the D...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Kumbhar, Ramhari, Vidal-Eychenié, Sophie, Kontopoulos, Dimitrios-Georgios, Larroque, Marion, Larroque, Christian, Basbous, Jihane, Kossida, Sofia, Ribeyre, Cyril, Constantinou, Angelos
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238597/
https://ncbi.nlm.nih.gov/pubmed/30456359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800096
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