Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in the D...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Life Sci Alliance
Prif Awduron: Kumbhar, Ramhari, Vidal-Eychenié, Sophie, Kontopoulos, Dimitrios-Georgios, Larroque, Marion, Larroque, Christian, Basbous, Jihane, Kossida, Sofia, Ribeyre, Cyril, Constantinou, Angelos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Life Science Alliance LLC 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238597/
https://ncbi.nlm.nih.gov/pubmed/30456359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800096
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