Mouse PVRIG Has CD8(+) T Cell–Specific Coinhibitory Functions and Dampens Antitumor Immunity

A limitation to antitumor immunity is the dysfunction of T cells in the tumor microenvironment, in part due to upregulation of coinhibitory receptors such as PD-1. Here, we describe that poliovirus receptor-related immunoglobulin domain protein (PVRIG) acts as a coinhibitory receptor in mice. Murine...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Murter, Benjamin, Pan, Xiaoyu, Ophir, Eran, Alteber, Zoya, Azulay, Meir, Sen, Rupashree, Levy, Ofer, Dassa, Liat, Vaknin, Ilan, Fridman-Kfir, Tal, Salomon, Ran, Ravet, Achinoam, Tam, Ada, Levin, Doron, Vaknin, Yakir, Tatirovsky, Evgeny, Machlenkin, Arthur, Pardoll, Drew, Ganguly, Sudipto
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038785/
https://ncbi.nlm.nih.gov/pubmed/30659055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0460
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