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The Role of Coinhibitory Signaling Pathways in Transplantation and Tolerance
Negative costimulatory molecules, acting through so-called inhibitory pathways, play a crucial role in the control of T cell responses. This negative “second signal” opposes T cell receptor activation and leads to downregulation of T cell proliferation and promotes antigen specific tolerance. Much i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Research Foundation
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3342378/ https://ncbi.nlm.nih.gov/pubmed/22566929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00047 |
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