A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug for over 90 days in vitro and in vivo. We evaluat...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Su, Jonathan T., Simpson, Solange M., Sung, Samuel, Tfaily, Ewa Bryndza, Veazey, Ronald, Marzinke, Mark, Qiu, Jiang, Watrous, David, Widanapathirana, Lakmini, Pearson, Elizabeth, Peet, M. Melissa, Karunakaran, Dipu, Grasperge, Brooke, Dobek, Georgina, Cain, Charlette M., Hope, Thomas, Kiser, Patrick F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038301/
https://ncbi.nlm.nih.gov/pubmed/31871073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01893-19
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