A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug for over 90 days in vitro and in vivo. We evaluat...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Su, Jonathan T., Simpson, Solange M., Sung, Samuel, Tfaily, Ewa Bryndza, Veazey, Ronald, Marzinke, Mark, Qiu, Jiang, Watrous, David, Widanapathirana, Lakmini, Pearson, Elizabeth, Peet, M. Melissa, Karunakaran, Dipu, Grasperge, Brooke, Dobek, Georgina, Cain, Charlette M., Hope, Thomas, Kiser, Patrick F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038301/
https://ncbi.nlm.nih.gov/pubmed/31871073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01893-19
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