A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug for over 90 days in vitro and in vivo. We evaluat...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Su, Jonathan T., Simpson, Solange M., Sung, Samuel, Tfaily, Ewa Bryndza, Veazey, Ronald, Marzinke, Mark, Qiu, Jiang, Watrous, David, Widanapathirana, Lakmini, Pearson, Elizabeth, Peet, M. Melissa, Karunakaran, Dipu, Grasperge, Brooke, Dobek, Georgina, Cain, Charlette M., Hope, Thomas, Kiser, Patrick F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038301/
https://ncbi.nlm.nih.gov/pubmed/31871073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01893-19
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