Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes

Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro. These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central scaffold through their amino groups; thus, their car...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Fikatas, Antonios, Vervaeke, Peter, Martínez-Gualda, Belén, Martí-Marí, Olaia, Noppen, Sam, Meyen, Eef, Camarasa, María-José, San-Félix, Ana, Pannecouque, Christophe, Schols, Dominique
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038274/
https://ncbi.nlm.nih.gov/pubmed/31932383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02130-19
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