A Novel Series of Indole Alkaloid Derivatives Inhibit Dengue and Zika Virus Infection by Interference with the Viral Replication Complex

Here, we identified a novel class of compounds which demonstrated good antiviral activity against dengue and Zika virus infection. These derivatives constitute intermediates in the synthesis of indole (ervatamine-silicine) alkaloids and share a tetracyclic structure, with an indole and a piperidine...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Fikatas, Antonios, Vervaeke, Peter, Meyen, Eef, Llor, Nuria, Ordeix, Sergi, Boonen, Ine, Bletsa, Magda, Kafetzopoulou, Liana Eleni, Lemey, Philippe, Amat, Mercedes, Pannecouque, Christophe, Schols, Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284442/
https://ncbi.nlm.nih.gov/pubmed/34001508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02349-20
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