Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR, and agrA. Pharmacokinetic simulations s...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Miller, Christopher R., Dey, Somrita, Smolenski, Paula D., Kulkarni, Pushkar S., Monk, Jonathan M., Szubin, Richard, Sakoulas, George, Berti, Andrew D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038235/
https://ncbi.nlm.nih.gov/pubmed/31932377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01593-19
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