Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR, and agrA. Pharmacokinetic simulations s...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Miller, Christopher R., Dey, Somrita, Smolenski, Paula D., Kulkarni, Pushkar S., Monk, Jonathan M., Szubin, Richard, Sakoulas, George, Berti, Andrew D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038235/
https://ncbi.nlm.nih.gov/pubmed/31932377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01593-19
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