Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Compound 1 is a curcumin di-O-2,2-bis(hydroxymethyl)propionate that shows significant in vitro and in vivo inhibitory activity against MDA-MB-231 cells with eight to ten-fold higher potency than curcumin. Here, we modified the α-position (C-4 position) of the central 1,3-diketone moiety of 1 with po...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Lee, Der-Yen, Hou, Yu-Chi, Yang, Jai-Sing, Lin, Hui-Yi, Chang, Tsu-Yuan, Lee, Kuo-Hsiung, Kuo, Sheng-Chu, Hsieh, Min-Tsang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7037731/
https://ncbi.nlm.nih.gov/pubmed/31979200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25030479
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados