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Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Compound <b>1</b> is a curcumin di-<i>O</i>-2,2-bis(hydroxymethyl)propionate that shows significant in vitro and in vivo inhibitory activity against MDA-MB-231 cells with eight to ten-fold higher potency than curcumin. Here, we modified the &#945;-position (C-4 position)...

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Detaylı Bibliyografya
Asıl Yazarlar: Der-Yen Lee, Yu-Chi Hou, Jai-Sing Yang, Hui-Yi Lin, Tsu-Yuan Chang, Kuo-Hsiung Lee, Sheng-Chu Kuo, Min-Tsang Hsieh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2020-01-01
Seri Bilgileri:Molecules
Konular:
Online Erişim:https://www.mdpi.com/1420-3049/25/3/479
Etiketler: Etiketle
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