Core 1–derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer

Core 1–derived mucin-type O-glycans (O-glycans) are a major component of gastric mucus with an unclear role. To address this, we generated mice lacking gastric epithelial O-glycans (GEC C1galt1(−/−)). GEC C1galt1(−/−) mice exhibited spontaneous gastritis that progressed to adenocarcinoma with ∼80% p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Liu, Fei, Fu, Jianxin, Bergstrom, Kirk, Shan, Xindi, McDaniel, J. Michael, McGee, Samuel, Bai, Xia, Chen, Weichang, Xia, Lijun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7037257/
https://ncbi.nlm.nih.gov/pubmed/31645367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182325
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