Blocking Substance P Signaling Reduces Musculotendinous and Dermal Fibrosis and Sensorimotor Declines in a Rat Model of Overuse Injury

Substance P-NK-1R signaling has been implicated in fibrotic tendinopathies and myositis. Blocking this signaling with a neurokinin 1 receptor antagonist (NK1RA) has been proposed as a therapeutic target for their treatment. Using a rodent model of overuse injury, we pharmacologically blocked Substan...

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Detalhes bibliográficos
Publicado no:Connect Tissue Res
Main Authors: Barbe, MF, Hilliard, B, Fisher, PW, White, AR, Delany, SP, Iannarone, VJ, Harris, MY, Amin, M, Cruz, GE, Popoff, SN
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036028/
https://ncbi.nlm.nih.gov/pubmed/31443618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03008207.2019.1653289
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