Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa using DNA-Encoded Small Molecule Library Screening

Pseudomonas aeruginosa is a leading cause of hospital-acquired infections in the United States. PqsE, a thioesterase enzyme, is vital for virulence of P. aeruginosa, making PqsE an attractive target for inhibition. Neither the substrate nor the product of PqsE catalysis has been identified. A librar...

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Udgivet i:ACS Chem Biol
Main Authors: Valastyan, Julie S., Tota, Michael R., Taylor, Isabelle R., Stergioula, Vasiliki, Hone, Graham A.B., Smith, Chari D., Henke, Brad R., Carson, Kenneth G., Bassler, Bonnie L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036018/
https://ncbi.nlm.nih.gov/pubmed/31880429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00905
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