Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production

[Image: see text] Pseudomonas aeruginosa is an opportunistic human pathogen that causes fatal infections. There exists an urgent need for new antimicrobial agents to combat P. aeruginosa. We conducted a screen for molecules that bind the virulence-controlling protein PqsE and characterized hit compo...

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Publicado en:ACS Chem Biol
Autores principales: Taylor, Isabelle R., Paczkowski, Jon E., Jeffrey, Philip D., Henke, Brad R., Smith, Chari D., Bassler, Bonnie L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2021
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056388/
https://ncbi.nlm.nih.gov/pubmed/33793200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.1c00049
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